Characteristics and clinical outcomes of breast cancer in young BRCA carriers according to tumor histology

E Agostinetto; M Bruzzone; AS Hamy; HJ Kim; C Chiodi; R Bernstein-Molho; S Linn; K Pogoda; E Carrasco; F Derouane; J Bajpai; G Nader-Marta; N Lopetegui-Lia; AH Partridge; L Cortesi; C Rousset-Jablonski; F Giugliano; T Renaud; A Ferrari; S Paluch-Shimon; R Fruscio; W Cui; SM Wong; C Vernieri; KJ Ruddy; MV Dieci; A Matikas; M Rozenblit; D Aguilar y Mendez; L De Marchis; R Borea; F Puglisi; M Pistelli; J Kufel-Grabowska; R Di Rocco; E Mariamidze; F Atzori; HR Kourie; L Popovic; E de Azambuja; E Blondeaux; M Lambertini

Journal article

Characteristics and clinical outcomes of breast cancer in young BRCA carriers according to tumor histology

E Agostinetto, M Bruzzone, AS Hamy, HJ Kim, C Chiodi, R Bernstein-Molho, S Linn, K Pogoda, E Carrasco, F Derouane, J Bajpai, G Nader-Marta, N Lopetegui-Lia, AH Partridge, L Cortesi, C Rousset-Jablonski, F Giugliano, T Renaud, A Ferrari, S Paluch-Shimon Show all

ESMO Open | Published : 2024

DOI: 10.1016/j.esmoop.2024.103714

Abstract

Background: Young women with breast cancer (BC) have an increased chance of carrying germline BRCA pathogenic variants (PVs). Limited data exist on the prognostic impact of tumor histology (i.e. ductal versus lobular) in hereditary breast cancer. Methods: This multicenter retrospective cohort study included women aged ≤40 years with early-stage breast cancer diagnosed between January 2000 and December 2020 and known to carry germline PVs in BRCA1/2. Histology was locally assessed in each center. The Kaplan–Meier method and Cox regression analysis were used to assess disease-free survival and overall survival. Results: Of 4628 patients included from 78 centers worldwide, 3969 (86%) had pure d..

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